MATTHEW KNOWLES

💼 Statistical Scientist, Astellas Pharma
📧 Email: mattknowles314[AT]gmail.com
🎓 MMath Mathematics, University of York (2022)
🎓 MSc Statistics with Medical Applications, University of Sheffield (2024)
🎓 PhD Mathematics, University of York (Ongoing)
📚 OrcId: 0000-0002-1197-8093

Personal Profile

I am a statistician in the Medical Affairs group at Astellas Pharma. In addition, I am currently working on my PhD in the Statistics and Probability group at the University of York. Previously, I was a senior statistical analyst at OPEN Health, working in the Modelling & Meta-Analysis department. I have several years of experience of clinical trial analysis and health technology assessment procedures. I started at OPEN Health after graduating with an MMath in Mathematics from the University of York. I also have an MSc in Statistics with Medical Applications from the University of Sheffield.

You can view my CV here.

Research

My primary area of interest is applied/computational statistics, particularly with applications to medicine and sport.

• Analysis of Clincal Trials
• Evidence Synthesis Methods and Application
• Computational Statistics
• Comparative Effectiveness Methods

In terms of medicine, I am primarily interested in the following indications:

• Oncology
• Neurology and Psychiatry
• Endocrinology
• Sports Medicine

Publications

2025

• Discrete Event-Simulation Model Projects Mepolizumab Treatment Outcomes Associated With Long-Term Clinical Remission in Severe AsthmaAlfonso Cristancho R, Begaj K, Dunnewind N, Knowles M, Jain D, Bennison C, Simons MJHG, Martin A. American Journal of Respiratory and Critical Care Medicine 211 A1383-A1383. May 2025.
• MSR48 Discrete-Event Simulation Model Projects Economic Outcomes Associated with Long-Term Clinical Remission in Patients with Severe Asthma Recieving Mepolizumab. Begaj K, Martin A, Valliant SN, Dunnewind N, Knowles M, Jain D, Bennison C, Simons MJHG, Alfonso Cristancho R. Value in Health. July 2025.

2024

• MSR213 Comparative Efficacy of Treatments in Advanced/Metastatic Pancreatic Cancer: Demonstrating the Power of Multilevel Network Meta-Regression. Knowles M, Ren S, Kroep S. Value in Health Volume 27, Issue 12. December 2024.